At the end of your turn, you may flip Tails, You Lose.
During your opponent’s turn, after your opponent plays a creature adjacent to a creature belonging to a different house, fulfill Tails, You Lose.
P14
Artist: Ilham Zaka
Commentary
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The second ability of Tails, You Lose will fulfill during the opponent's turn after playing a creature adjacent to a card that is different from the played creature's house. If the existing card in the battleline belongs to 1 or more houses that the played card does not belong to, Tails, You Lose is fulfilled. The prophecy fulfills at the same time as other "after play" effects resolve, which is after any bonus icons on the played creature resolve.